进驻不同海拔高原健康男青年肾功能的变化

目的探讨移居不同海拔高度高原健康男青年肾功能的变化。方法对从平原进驻海拔3700 m和5380 m3个月的某部各10名官兵进行血尿素氮（BUN）、血清肌酐（SCr）、尿酸（UA）及胱抑素C（Cys C）检测,并与20名平原（海拔1400 m）健康男青年作对照。结果进驻高原3个月后,高原组的BUN、SCr、UA、Cys C均明显高于平原组（P〈0.01）,且随海拔高度的升高而增高（P〈0.05或P〈0.01）。结论高原低氧环境导致肾小球滤过、肾小管重吸收和分泌功能都产生相应的损害,且这种损害随着海拔高度的升高而增强。

Changes of renal function in healthy young men arrived at different high altitudes

Objective To explore the changes of renal function in healthy young men arrived at different high altitudes.Methods 10 soldiers and officers as well as other 10 ones in a troop arrived separately at 3700 m and 5380 m altitude for three months from the plain（1400 m above sea level） were served as high altitude Ⅰ group and high altitude Ⅱ group,respectively.Meanwhile,another 20 healthy young men in the plain were served as the control group.Blood urea nitrogen（Bun）,serum creatinine（SCr）,uric acid（UA） and cystatin C（Cys C） of each subject were measured and compared one another.Results The levels of Bun,SCr,UA and Cys C in the two high altitude groups were significantly higher than those in the plain group（P0.01）.Moreover,the levels of these indexes increased with the elevation of altitude（P0.05 or P0.01）.Conclusion High altitude hypoxia can damage renal function including glomerular filtration,tubular reabsorption and secretion,and the higher the altitude is,the more the impairment are.