| HPV检测在“不典型鳞状细胞-不除外宫颈高度上皮内病变”中的意义 |
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| 引用本文： | 张小燕,卞美璐,陈庆云. HPV检测在“不典型鳞状细胞-不除外宫颈高度上皮内病变”中的意义[J]. 基础医学与临床, 2011, 31(7) |
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| 作者姓名： | 张小燕 卞美璐 陈庆云 |
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| 作者单位： | 1. 北京市海淀区妇幼保健院,妇产科,北京,100080
2. 北京中日友好医院,妇产科,北京,100029 |
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| 摘 要： | 目的探讨高危型人乳头状瘤病毒(HR-HPV)检测对细胞病理学诊断为不典型鳞状细胞-不除外宫颈高度上皮内病变的(ASC-H)患者的临床处理价值。方法 2004年6月～2007年4月于中日友好医院妇产科门诊进行宫颈细胞学检查的患者17 125例,选择其中细胞学诊断结果为不典型鳞状细胞的患者,应用第二代杂交捕获方法检测HR-HPV,观察HR-HPV检测对细胞学诊断结果为ASC-H进行分流的意义。结果 HR-HPV阳性的ASC-H患者中宫颈高度病变的检出率(48.1%)显著高于ASC-US(25.2%),(P<0.01)。13例HR-HPV阴性的ASC-H患者中1例宫颈活组织检查结果为CIN2(5.9%),与ASC-US(5.7%)相比无差异。在ASC-US和ASC-H患者中,HR-HPV检测对于宫颈高度病变的敏感性分别为82.8%、96.2%,阴性预告值分别为94.3%,92.3%。结论对于HR-HPV阴性的ASC-H患者可以考虑定期随诊细胞学和高危型HPV,减少阴道镜检查,HR-HPV检测可能对于ASC-H患者同样具有分流作用。
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| 关 键 词： | 人乳头状瘤病毒 细胞学 阴道镜 |
Clinical significance of the triage role of HR-HPV for atypical squamous cells,cannot exclude high-grade squamous intraepithelial lesion |
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| ZHANG Xiao-yan,BIAN Mei-lu,CHEN Qing-yun. Clinical significance of the triage role of HR-HPV for atypical squamous cells,cannot exclude high-grade squamous intraepithelial lesion[J]. Basic Medical Sciences and Clinics, 2011, 31(7) |
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| Authors: | ZHANG Xiao-yan BIAN Mei-lu CHEN Qing-yun |
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| Affiliation: | ZHANG Xiao-yan1,BIAN Mei-lu2,CHEN Qing-yun2(1.Dept.of Obstetrics and Gynecology,Haidian maternal and children healthcare Hospital,Beijing 100080,2.Dept.of Obstetricsand Gynecology,China-Japan Friendship Hospital,Beijing 100029,China) |
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| Abstract: | Objective To evaluate the possible role of HR-HPV testing for ASC-H in clinical practice.MethodsAmong 17 125 cervical smesrs in China-Japan friendship hospital from June 2004 to April 2007,those interpreted as ASC and those had HR-HPV testing were enrolled in the study.The possible role of triage of HR-HPV testing for ASC-H was evaluated according to the results of biopsy.Results CIN 2/3 was identified in 25 of 52(48.1%) patients with HR-HPV positive ASC-H compared with 48 of 190(25.2%)patients with HR-HPV ... |
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| Keywords: | high risk human papillomavirus cytology colposcopy |
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