Effects of tetragastrin on mucus glycoprotein in rat gastric mucosal protection |
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Authors: | Yuichi Komuro Kazuhiko Ishihara Susumu Ohara Katsunori Saigenji Kyoko Hotta |
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Institution: | 1. Department of Biochemistry, School of Medicine, Kitasato University, Sagamihara, 228, Kanagawa, Japan 2. Departments Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan
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Abstract: | The effects of tetragastrin on mucus glycoprotein (mucin) metabolism and mucosal protection in rat gastric mucosa were investigated.
Rats were administered with various doses of tetragastrin (12, 120, or 400 μg/kg body weight; s.c), followed by 50% ethanol-induced
gastric injury. Tetragastrin caused a significant increase in mucin content in the corpus mucosa and prevented 50% ethanol-induced
gastric mucosal damage in a dose-dependent manner. For assessment of the effects of tetragastrin on the metabolism of gastric
mucin in detail, changes in mucin distribution in the three different layers of rat gastric mucosa were examined one hour
after single administration of tetragastrin. A significant increase in the mucin content was noted in the mucus gel and surface
mucosal layer. Mucin content in the deep mucosa corresponding mainly to the mucus neck cell mucin underwent virtually no change
by this treatment. An increase in mucin in the mucus gel and surface mucosa would thus appear due to the administration of
tetragastrin and may possibly be related to the protective action of the gastric mucosa against injury. The data demonstrate
a possibility that gastrin may have potential for enhancing gastric mucosal protection associated with mucus secretion and/or
mucus synthesis on the surface mucosa of rat gastric mucosa. |
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Keywords: | deep mucosa ethanol-induced gastric damage mucus gel mucosal protection mucus glycoprotein (mucin) surfacemocosa tetragastrin |
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