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Effect of phenacetin and N-alkylacetanilides on N-2-fluorenylacetamide hepatocarcinogenesis |
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| Authors: | R S Yamamoto H H Frankel E K Weisburger |
| Affiliation: | Laboratory of Carcinogen Metabolism, DCCP, National Cancer Institute, NIH, Bethesda, Maryland 20205 U.S.A. |
| Abstract: | Phenacetin, N-methylacetanilide and N-ethylacetanilide prevented N-2-fluorenylacetamide hepatocarcinogenesis in F344 strain rats. Phenacetin was most effective followed by N-ethylacetanilide. Phenacetin was not carcinogenic when fed at 0.8% level for 16 weeks followed by control diet for another 10 weeks. |
| Keywords: | Address all correspondence to: Dr. Richard S. Yamamoto Building 37 Room 3B27 Nutrition and Metabolism Section Laboratory of Carcinogen Metabolism National Cancer Institute National Institutes of Health Bethesda Maryland 20205 U.S.A. |
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