| miRNA功能研究进展 |
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| 引用本文： | 张卓远,付汉江,吕星,郑晓飞.miRNA功能研究进展[J].军事医学科学院院刊,2005,29(6):571-575. |
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| 作者姓名： | 张卓远 付汉江 吕星 郑晓飞 |
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| 作者单位： | 军事医学科学院放射与辐射医学研究所,北京,100850 |
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| 基金项目： | 国家自然科学基金（30500299）资助项目 |
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| 摘 要： | miRNA是一类长度为20~25nt的小分子非编码RNA。在线虫、小鼠、人、植物等多种生物中已发现了数百种miRNA。无论在低等的线虫还是在高等的哺乳动物中，miRNA都起着调控基因表达的重要作用。生物信息学分析表明人类全部基因的三分之一都受到miRNA的调控。这表明，miRNA分子实际上是基因调控网络中的核心成分。近来研究发现miRNA与人类的某些疾病密切相关。本文对miRNA分子功能及其研究方法的进展做一概述。
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| 关 键 词： | miRNA 功能 基因表达调控 |
| 文章编号： | 1000-5501（2005）06-0571-05 |
| 收稿时间： | 2005-03-30 |
| 修稿时间： | 2005-03-30 |
Progress in research on miRNA function |
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| ZHANG Zhuo-Yuan,FU Han-Jiang,L Xing,ZHENG Xiao-Fei.Progress in research on miRNA function[J].Bulletin of the Academy of Military Medical Sciences,2005,29(6):571-575. |
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| Authors: | ZHANG Zhuo-Yuan FU Han-Jiang L Xing ZHENG Xiao-Fei |
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| Institution: | ZHANG Zhuo-Yuan,FU Han-Jiang,L(U) Xing,ZHENG Xiao-Fei |
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| Abstract: | Mature miRNAs are noncoding RNAs of about 20-25 nucleotides in length. Hundreds of them have been found in the genomes of plants,invertebrates and vertebrates. The research suggested that the miRNAs play a great role in the regulation of gene expression. Bioinformatics tells us that about 1/3 of total human genes are regulated by the miRNAs, suggesting that the miRNAs are the core component of the gene regulation network. Some of them are also related to some human diseases. The research of miRNA in the recent years is reviewed. |
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| Keywords: | miRNA function gene expression regulation |
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