| 他克莫司软膏治疗白癜风的系统评价 |
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| 引用本文： | 陈小玫,汪盛,黄旭蕾.他克莫司软膏治疗白癜风的系统评价[J].中国皮肤性病学杂志,2010,24(2). |
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| 作者姓名： | 陈小玫 汪盛 黄旭蕾 |
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| 作者单位： | 四川大学华西医院皮肤性病科,四川,成都,610041 |
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| 摘 要： | 目的系统评价外用他克莫司软膏治疗白癜风的临床疗效及安全性。方法计算机检索Cochorane图书馆、Pubmed,Embase、中国生物医学文献数据库、中国期刊全文数据库、万方学位论文数据库,收集所有外用他克莫司软膏治疗白癜风的随机对照试验(RCT),对其进行系统评价。结果共纳入13篇RCT。Meta分析显示他克莫司软膏联合308nm准分子激光或窄谱中波紫外线(NB-UVB)疗效优于单用308nm准分子激光或NB-UVB;单用他克莫司软膏疗效优于补骨脂醑,但与单用NB-UVB、卤米松或0.05%丙酸氯倍米松比较,疗效差异无显著性。他克莫司软膏的主要不良反应是皮肤烧灼感和红斑。结论他克莫司软膏是治疗白癜风的新选择,但临床应用的确切有效性和安全性尚需更多的RCT证实。
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| 关 键 词： | 白癜风 他克莫司 随机对照试验 窄谱中波紫外线 308nm准分子激光 |
Efficacy of Topical Tacrolimus in the Treatment of Vitiligo:a Systematic Review of Randomized Controlled Trials |
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| CHEN Xiao-mei,WANG Sheng,HUANG Xu-lei.Efficacy of Topical Tacrolimus in the Treatment of Vitiligo:a Systematic Review of Randomized Controlled Trials[J].The Chinese Journal of Dermatovenereology,2010,24(2). |
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| Authors: | CHEN Xiao-mei WANG Sheng HUANG Xu-lei |
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| Institution: | CHEN Xiao-mei,WANG Sheng,HUANG Xu-lei(Department of Dermatovenereology,West China Hospital,Sichuan University,Chengdu 610041,China) |
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| Abstract: | Objective To systematically evaluate the efficacy and tolerability of topical tacrolimus for vitiligo.Methods Randomized controlled trials (RCTs) of treatment with topical tacrolimus in vitiligo reporting efficacy outcome or tolerability were selected through electronic searches of the Cochrane Library,Pubmed,Embase,CBM,CNKI and Wan Fang Database.Results Thirteen RCTs were included.Meta-analysis indicated that the combination treatment of 0.1% tacrolimus ointment plus the 308-nm excimer laser or narrow band... |
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| Keywords: | Vitiligo Tacrolimus Randomized controlled trials NB-UVB 308nm excimer laser |
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