Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy |
| |
Authors: | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Osamu Togawa Hirofumi Kogure Yukiko Ito Keisuke Yamamoto Suguru Mizuno Hiroshi Yagioka Yoko Yashima Kazumichi Kawakubo Toshihiko Arizumi Saburo Matsubara Naoki Sasahira Kenji Hirano Takeshi Tsujino Nobuo Toda Minoru Tada Masao Omata Kazuhiko Koike |
| |
Institution: | 1. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan 2. Department of Gastroenterology, Japanese Red Cross Medical Center, Tokyo, Japan 3. Department of Gastroenterology, JR Tokyo General Hospital, Tokyo, Japan 4. Department of Gastroenterology, Kanto Central Hospital, Tokyo, Japan 5. Department of Gastroenterology, Mitsui Memorial Hospital, Tokyo, Japan
|
| |
Abstract: | Purpose Prognostic factors for patients with advanced biliary tract cancer receiving chemotherapy are presently not well established. Gallbladder cancer and intra-hepatic cholangiocarcinoma are previously reported prognostic factors of poor prognosis; however, tumor volume has not been analyzed in these previous reports. Methods We analyzed 56 consecutive patients with advanced biliary tract cancer who had received gemcitabine and S-1 combination chemotherapy as first-line palliative chemotherapy. Prognostic factors, including the baseline sum longest diameter (BSLD) representing tumor volume in Response Evaluation Criteria in Solid Tumor, were evaluated. Results By multivariate analysis, age ??70 (HR 3.01, 95% CI 1.25?C7.31, P?=?0.014) and larger BSLD (HR 1.09, 95% CI 1.01?C1.18, P?=?0.021) were statistically significant independent predictors of poor prognosis. Primary biliary site was not identified as a prognostic factor (P?=?0.728). Median survival times of patients with BSLDs????9.0?cm and BSLDs?>?9.0?cm were 18.7 and 8.8?months, respectively (P?=?0.024). Conclusions Age and BSLD were identified as strong prognostic factors for patients with advanced biliary tract cancer receiving chemotherapy. Tumor volume might be more important than primary biliary site for the prognosis of advanced biliary tract cancer. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|