Genomic surgery for lung cancer |
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| Authors: | Schrump David S |
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| Affiliation: | Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. david_Schrump@nih.gov |
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| Abstract: | An emerging body of literature indicates that reversible alterations in chromatin structure modulate gene expression during malignant transformation. Chromatin structure is regulated in part by DNA methylation and histone acetylation; these independent yet highly interrelated epigenetic processes are influenced by a variety of signal transduction pathways. The present review highlights recent advances regarding cancer epigenetics, focusing on the potential utilization of chromatin remodeling agents to induce apoptosis and enhance the immunogenicity of thoracic malignancies. |
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| Keywords: | 5-aza-2′-deoxycytidine Depsipeptide FK228 lung cancer tumor suppressor gene cancer-testis antigen |
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