|
|||||
|
|
Reduced coxsackie antibody titres in Type 1 (insulin-dependent) diabetic patients presenting during an outbreak of coxsackie B 3 and B 4 infection |
|
| Authors: | J. P. Palmer M.D. M. K. Cooney R. H. Ward J. A. Hansen J. B. Brodsky C. G. Ray J. R. Crossley C. M. Asplin R. H. Williams |
| Affiliation: | (1) Diabetes Research Center, Department of Medicine, University of Washington, Seattle, Washington;(2) Diabetes Research Center, Departments of Epidemiology and Pathobiology, University of Washington, Seattle, Washington;(3) Puget Sound Blood Center, University of Auckland, Auckland, New Zealand;(4) Department of Pediatrics, University of Auckland, Auckland, New Zealand;(5) Diabetes Research Center (ZB-34) Seattle Public Health Hospital, Quarters 8, 1131-14th Avenue South, W 98144 Seattle, USA;(6) Present address: Dept. of Medical Genetics, University of British Columbia, Vancouver, B. C., Canada;(7) Present address: Dept. of Pathology and Pediatrics, University of Arizona, Tucson, Arizona, USA |
| Abstract: | Summary The potential role of antecedent viral infection in the pathogenesis of Type 1 (insulin-dependent) diabetes was investigated by measuring antibody titres to several viruses in serum obtained at the time of diagnosis of diabetes. An outbreak of Coxsackie B 4 infection folio wed by a wave of Coxsackie B 3 and B 5 infections occurred in Seattle during the time viral serology was obtained in the diabetic patients. Antibody titres to Cocksackie B 5 and Influenza A and B viruses were comparable in diabetics and matched control subjects, but antibody titres to Cocksackie B 3 and B 4 were lower in the diabetics and a low antibody titre to Coxsackie B 3/B 4 was associated with a significantly increased relative risk of diabetes. |
| Keywords: | Type 1 diabetes virus Coxsackie B 4 antibody titres |
| 本文献已被 SpringerLink 等数据库收录！ | |