慢性肝病中血清前白蛋白检测的临床意义探讨

目的探讨慢性肝病中血清前白蛋白检测的临床意义。方法研究组82例,均为慢性肝病患者,对照组80例为我院体验健康者;对两组研究对象进行空腹静脉抽血,并分别检测血清前白蛋白(PA)、血清白蛋白(ALB)、凝血酶原时间(PT)值,对比分析。结果研究组患者的PA值明显低于对照组,ALB值低于对照组,PT值高于对照组,经统计学比较均有显著差异(P<0.05);慢性乙肝患者随着病情的加重,其PA值明显降低,中度、重度患者的PA值与轻度比较有显著差异,重度与中度比较也具有显著差异(P<0.05);肝硬化患者中,失代偿期患者的PA值明显低于代偿期,经统计学分析具有显著差异(P<0.05)。ALB、PT仅重度慢性乙肝、肝硬化失代偿期、原发性肝癌与对照组比较差异具有显著性(P<0.05)。结论 PA对检测慢性肝病患者的肝脏损伤程度具有极强的敏感性,患者肝脏受损程度越重,其PA检测值越低。

Study on clinical significance of serum level of prealbumin (PA) in patients with chronic liver diseases

Objective To discuss the clinical significance of serum level of prealbumin（PA） in patients with chronic liver diseases.Methods Eighty two patients with chronic liver diseases were allocated in study group,and 80 healthy persons were allocated in control group.Serum levels of PA,ALB,and PT were examined in all patients of these two groups.Results The serum levels of PA and ALB in patients of study group were significantly lower than those of control group,and their serum level of PT was higher than that of control group（P0.05）.Following the worsening of condition in patients with chronic hepatitis B,the serum level of PA was significantly decreased.Cirrhotic patients,decompensated patients with PA was significantly lower than compensated by the difference statistically significant（P 0.05）.ALB,PT only severe chronic hepatitis B,decompensated cirrhosis,primary liver cancer compared with the control group was significant difference（P0.05）.Conclusion Serum level of PA is extremely sensitive in assessment of the degree of liver damage in patients with chronic liver diseases,and the degree of severity of liver damage is inversely proportional to the serum level of PA.