| 星点设计-效应面法优化盐酸二甲双胍缓释片处方 |
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| 引用本文： | 谈颖,林巧平,刘春晖,狄留庆. 星点设计-效应面法优化盐酸二甲双胍缓释片处方[J]. 安徽医药, 2011, 15(7): 817-819 |
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| 作者姓名： | 谈颖 林巧平 刘春晖 狄留庆 |
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| 作者单位： | 南京中医药大学,江苏,南京,210046;江苏先声药物研究有限公司,江苏,南京,210042;江苏先声药物研究有限公司,江苏,南京,210042;南京中医药大学,江苏,南京,210046 |
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| 摘 要： | 目的 应用星点设计-效应面法优化盐酸二甲双胍缓释片的处方.方法 以HPMC K100M的用量和Carbopol 71GNF的用量为考察因素,以1,3,6和10 h的累积释放度为考察指标,采用多元线性回归和多元非线性回归拟合选择合适的模型,根据最佳模型绘制效应面图和等高线图,选择最佳处方并进行验证.采用相似因子对自研片和...
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| 关 键 词： | 盐酸二甲双胍 缓释片 处方优化 星点设计-效应面法 |
Optimization of metformin hydrochloride sustained-release tablets by central composite design/response surface methodology |
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| TAN Ying,LIN Qiao-ping,LIU Chun-hui,DI Liu-qing. Optimization of metformin hydrochloride sustained-release tablets by central composite design/response surface methodology[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(7): 817-819 |
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| Authors: | TAN Ying LIN Qiao-ping LIU Chun-hui DI Liu-qing |
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| Affiliation: | TAN Ying1,2,LIN Qiao-ping2,LIU Chun-hui2,DI Liu-qing1(1.Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210046,China,2.Jiangsu Simcere Medicines Research Co.Ltd,Jiangsu 210042,China) |
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| Abstract: | Aim To optimize the formulation of metformin hydrochloride sustained-release tablets by central composite design/response surface methodology(CCD).Methods The independent variables were the amount of HPMC K100M and Carbopol 71GNF,and the dependent variables were the dissolution of metformin hydrochloride at 1,3,6,10 h.Linear or nonlinear mathematic models were used to estimate the relationship between the independent and the dependent variables.Response surface and 2D-contour map were delineated according t... |
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| Keywords: | metformin hydrochloride sustained-release tablets optimization of the formulation central composite design/response surface methodology |
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