| 慢性牙周炎龈沟液中KGF-1含量检测及其意义 |
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| 引用本文： | 赵哲,武云霞,孙晓军.慢性牙周炎龈沟液中KGF-1含量检测及其意义[J].临床口腔医学杂志,2011,27(2):70-72. |
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| 作者姓名： | 赵哲 武云霞 孙晓军 |
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| 作者单位： | 山西医科大学附属第一医院口腔科,山西,太原,030001 |
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| 摘 要： | 目的：检测慢性牙周炎患者牙周基础治疗前及治疗后不同时期龈沟液中角质细胞生长因子（keratinocytegrowth factor,KGF）-1的质量浓度,探讨KGF-1与牙周炎的关系及其在牙周炎发病机理、病情进展方面的作用。方法：用滤纸条浸润法采集牙周健康者和慢性牙周炎患者治疗前后不同时期的龈沟液样本,用酶联免疫吸附测定法检测样本中KGF-1的质量浓度。结果：慢性牙周炎患者龈沟液中KGF-1的质量浓度高于健康对照组（P〈0.05）,牙周基础治疗后第4、6、8周复查,KGF-1的质量浓度低于治疗前,且治疗后不同时期的复查结果与治疗前相比,均有统计学意义（P〈0.05）,KGF-1的质量浓度与牙周探诊深度（PD）、附着丧失（AL）、龈沟出血指数（SBI）存在正相关。结论：龈沟液中KGF-1水平与牙周炎症密切相关,KGF-1可作为反映牙周状态的客观指标。
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| 关 键 词： | 牙周炎 龈沟液 KGF-1 |
Detection and clinical benefits of keratinocyte growth factor KGF-1 in gingival crevicular fluid in the patients with perlodontitis |
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| ZHAO Zhe,WU Yun-xia,SUN Xiao-jun.Detection and clinical benefits of keratinocyte growth factor KGF-1 in gingival crevicular fluid in the patients with perlodontitis[J].Journal of Clinical Stomatology,2011,27(2):70-72. |
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| Authors: | ZHAO Zhe WU Yun-xia SUN Xiao-jun |
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| Institution: | ZHAO Zhe,WU Yun-xia,SUN Xiao-jun.Department of Stomatology,the First Affiliated Hospital of Shanxi Medical University,Shanxi Taiyuan,030001,China |
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| Abstract: | Objective:To detect the concentration of keratinocyte growth factor(KGF)-1 in gingival crevicular fluid(GCF) in the patients with chronic periodontitis before treatment and in different periods after treatment,to research the relationship between KGF-1 in GCF and periodontitis and the effect of KGF-1 in pathogenesis of periodontitis and its progressiveness.Method:The concentration of KGF-1 in GCF were detected by way of enzyme-linked immunosorbent assay following careful sampling of GCF with the standardize... |
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| Keywords: | KGF-1 |
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