| 神经预变性促进周围神经桥接后神经再生的初步研究 |
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| 引用本文： | 张文明,吴朝阳,张立群.神经预变性促进周围神经桥接后神经再生的初步研究[J].临床和实验医学杂志,2011,10(10):723-724. |
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| 作者姓名： | 张文明 吴朝阳 张立群 |
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| 作者单位： | 福建医科大学附属第一医院骨科,福建,福州,350004 |
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| 摘 要： | 目的探讨经过体内预变性的神经用于周围神经缺损桥接修复的效果。方法 SD大鼠20只,制作右侧坐骨神经压榨伤动物模型,3 d后,取坐骨神经用于对侧行神经桥接,在桥接后0 d、3 d、7 d、14 d取材,应用ED1和NF200染色比较双侧神经再生速度及神经纤维内巨噬细胞浸入情况。结果压榨伤后3 d,远端神经纤维内见大量ED1染色阳性巨噬细胞侵入,NF200阳性染色成棒状或碎片状;神经桥接后3 d、7 d、14 d,预变性组与对照组桥接远端均可见大量ED1染色阳性巨噬细胞侵入,经过预变性的神经内神经再生速度明显提高。结论 经过体内预变性的神经用于周围神经缺损桥接修复可明显促进神经再生,其机制可能是巨噬细胞的早期侵入,有利于神经生长抑制物的清除。
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| 关 键 词： | 大鼠神经变性 神经再生 周围神经 神经桥接 |
Preliminary study on the transplantation of pre-degenerated nerve promote peripheral neural regeneration after bridging repair |
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| ZHANG Wen-ming,WU Chao-yang,ZHANG Li-qun.Preliminary study on the transplantation of pre-degenerated nerve promote peripheral neural regeneration after bridging repair[J].Journal of Clinical and Experimental Medicine,2011,10(10):723-724. |
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| Authors: | ZHANG Wen-ming WU Chao-yang ZHANG Li-qun |
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| Institution: | ZHANG Wen-ming,WU Chao-yang,ZHANG Li-qun.Department of orthopeadics,The First Affiliated Hospital of Fujian Medical University,Fuzhou Fujian 350004,China. |
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| Abstract: | Objective To evaluated the effect of transplantation of pre-degenerated nerve on the bridging repair of peripheral nerve defect.Methods Twenty SD rats were used to build right side sciatic nerve crash model.Three day after injury,contralateral nerves were harvest for nerve bridging transplantation.The speed of regeneration and the penetration of macrophage cells on both sides of sciatic nerves were observed using ED1 and NF200 immunostaining.Results Three days after crash injury,massive macrophage cells pen... |
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| Keywords: | Rat Neural degeneration Nerve regeneration Peripheral nerve Nerve bridging |
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