| 球晶造粒技术制备可直压乙基纤维素及适应性研究 |
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| 引用本文： | 高松,胡容峰,白中稳,车富强. 球晶造粒技术制备可直压乙基纤维素及适应性研究[J]. 安徽医药, 2011, 15(7): 809-811 |
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| 作者姓名： | 高松 胡容峰 白中稳 车富强 |
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| 作者单位： | 安徽中医学院药学院,安徽,合肥,230031;安徽省中药研究与开发重点实验室,安徽,合肥,230038;安徽中医学院药学院,安徽,合肥,230031;安徽省中药研究与开发重点实验室,安徽,合肥,230038;安徽省"115"现代中药研发创新团队,安徽,合肥,230038 |
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| 基金项目： | 2009年度安徽省高层次人才创新创业资金，安徽高校省级自然科学研究重点项目 |
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| 摘 要： | 目的 评价进口、国产乙基纤维素(EC)及球晶技术自制EC聚集体对药物的适应性.方法 分别以阿司匹林含量为10%～90%与进口、国产乙基纤维素(EC)及自制EC聚集体混合后直接压片,测定混合物粉体学性质如休止角,流出速度,卡氏指数及压片后的片重差异、脆碎度、硬度,以考察聚集体对药物的稀释潜力.结果 与国产及进口乙基纤...
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| 关 键 词： | 乙基纤维素 阿司匹林 球晶造粒 流动性 稀释潜力 |
Adaptability of ethylcellulose for direct compression by spherical crystallization technique |
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| GAO Song,HU Rong-feng,BAI Zhong-wen,CHE Fu-qiang. Adaptability of ethylcellulose for direct compression by spherical crystallization technique[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(7): 809-811 |
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| Authors: | GAO Song HU Rong-feng BAI Zhong-wen CHE Fu-qiang |
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| Affiliation: | GAO Song1,2,HU Rong-feng1,3,BAI Zhong-wen1,CHE Fu-qiang1,2(1.School of Pharmacy,Anhui College of Traditional Chinese Medicine,Hefei 230031,China,2.Key Laboratory of R & D of Chinese Medicine in Anhui Province,Hefei 230038,3.Anhui 115 Modern Traditional Chinese Medicine Innovation Team,China) |
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| Abstract: | Aim To evaluate adaptability of imported,domestic ethylcellulose and self-made ethylcellulose agglomeration by spherical crystallization technique.Methods Different proportion of aspirin(10%~90%)were tableted with three kinds of EC which was made of Shanhe excipient Ltd.,Coloton Ltd.and our lab,respectively.The micromeritics properties of the mixture such as angle of repose,flow velocity,carr's index and standard deviation,friability,hardness were determined as to investigate the dilution potential.Results ... |
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| Keywords: | ethylcellulose aspirin spherical crystallization flowability dilution potential |
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