肺癌相关抗原检测对非小细胞肺癌的诊断意义

目的探讨肺癌相关抗原（lung tumor antigen LTA）在纤维支气管镜支气管肺泡灌洗液、胸水和血清中的检测结果对肺癌的临床诊断意义。方法收集72例非小细胞肺癌（non-small cell lung cancerNSCLC）伴胸腔积液患者和对照组68例肺部良性病变（benign lungdisease BLD）患者的支气管肺泡灌洗液、胸水及血清样本，运用LTA检测试剂用快速乳胶凝集法分别检测，并对所得数据进行统计分析。结果肿瘤组病人支气管肺泡灌洗液、胸水和血清的LTA检测阳性率分别为58％、67％和75％，对照组三者的阳性检出率分别为22％、17％和20％，两组比较均有明显差异（P〈0．05）。LTA阳性检出率以肿瘤组的血清样本最高，达75％。特异性以胸水样本最高，为82％。结论支气管肺泡灌洗液、胸水和血清IJTA检测对肺癌的诊断有一定的临床参考意义。

Clinical diagnostic value of lung tumor antigen in lung cancer

Objective To explore the clinical diagnostic value of LTA in lung eanaer Methods Patients were divided into two groups： non-small cell lung cancer（n = 72） ; bengln lung disease （n = 68 ）. The LTA levels in BLAF,pleural effusion f; luid and serum were detected by latex agglutination method. Results The NSCLC group：positive rate for LTA in BLAF ,pleural effusion and serum were 58% ,67% ,75%. While 22% ,17% ,20% in the control group. The difference between the two groups is significant（ P 〈 0.05 ）. Posi- tive rate of LTA in serum of the NSCLC group was the highest ,75%. The peculiarty for LTA in pleural effusion at the NSCLC group was the highest, 82%. Conclusion These results suggested that detection of LTA in BLAF,pleural effusion and serum is a valuable method for the diagnosis of lung cancer.