涎腺腺样囊性癌COX-2表达与肿瘤血管生成的研究

目的：探讨环氧化酶-2（Cycloxygenase-2,COX-2）表达与涎腺腺样囊性癌（salivary adenoid cystic carcino-ma,SACC）血管生成的关系。方法：免疫组化法检测SACC中COX-2、诱导型一氧化氮合酶（inducible nitric oxide synthase,iNOS）、血管内皮生长因子（vascular endothelial growth factor,VEGF）表达,并测定肿瘤微血管密度（microvessel density,MVD）。结果：SACC中COX-2表达与VEGF、iNOS表达密切相关（P〈0.05,P〈0.01）。SACC中COX-2表达阳性组和阴性组MVD有显著差异（P〈0.01）.结论：SACC中COX-2表达和肿瘤血管生成有关,iNOS和VEGF可能参与COX-2对肿瘤血管生成的促进作用。

Study of COX-2 expression and angiogenesis in salivary adenoid cystic carcinoma

Objective：To explore the relationships between Cycloxygenase-2（COX-2） expression and angiogenesis in salivary adenoid cystic carcinoma（SACC）.Method：The COX-2 expression,inducible nitric oxide synthase（iNOS） and vascular endothelial growth factor（VEGF） expression,microvessel density（MVD） were evalulated by immunohistochemical method.Result：The expressions of COX-2 and iNOS、VEGF in SACC were significantly positively correlated（P0.05,P0.01）.There was significant difference of MVD between COX-2 positive SACC and negative ones（P0.05）.Conclusion：The present findings suggest that there is some link between COX-2 and angiogenesis in SACC,partly attributing to the effect of VEGF and iNOS.