| 索拉非尼对人肺腺癌细胞株A549抑制作用的研究 |
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| 引用本文： | 张媛媛,吕喜英.索拉非尼对人肺腺癌细胞株A549抑制作用的研究[J].临床肺科杂志,2011,16(5):728-729. |
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| 作者姓名： | 张媛媛 吕喜英 |
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| 作者单位： | 承德,承德医学院附属医院放化疗科,河北,067000 |
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| 摘 要： | 目的探讨索拉非尼（Sorafenib）在体外对人肺腺痛细胞株A549增殖、凋亡的影响。方法采用MTT法检测Sor-afenib对A549细胞增殖抑制率，应用流式细胞仪检测细胞凋亡率。结果Sorafenib在1．5～12．20μmol／L浓度范围内能明显抑制A549细胞的增殖，此抑制作用呈时间-剂量依赖效应（P〈0．05），而不同药物浓度的Sorafenib作用于A549细胞72h，显著增加其凋亡率，呈剂量依赖性，差异有显著性（P〈0．05）。结论Sorafenib能抑制人肺腺癌细胞株A549细胞增殖，呈时间-剂量依赖效应，还能促进A549细胞凋亡，亦呈剂量依赖性。
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| 关 键 词： | Sorafenib A549 增殖 凋亡 |
Depressant effects of Sorafenib on human pulmonary adenocarcinoma cell line A549 |
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| ZHANG Yuan-yuan,L Xi-ying.Depressant effects of Sorafenib on human pulmonary adenocarcinoma cell line A549[J].Journal of Clinical Pulmonary Medicine,2011,16(5):728-729. |
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| Authors: | ZHANG Yuan-yuan L Xi-ying |
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| Institution: | ZHANG Yuan-yuan,L(U) Xi-ying |
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| Abstract: | Objective To investigate the depressant effects of Sorafenib on human pulmonary adenocarcinoma cell line A549 in vitro.Methods MTT method was used to detect the anti-proliferative ratio of Sorafenib on A549 cells,flow cytometry were used to analyze apoptotic ratio of A549 cells.Results The depressant effects of Sorafenib on human pulmonary Aden-carcinoma cell line A549 were determined by MTT assay after at 24h,48h,and 72 h after the addition of Sorafenib to A549 cells.The concentration of Sorafenib was 1.5m... |
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| Keywords: | Sorafenib A549 |
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