Medicinal chemistry of Hsp90 inhibitors |
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Authors: | Drysdale Martin J Brough Paul A |
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Affiliation: | Vernalis R&D Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, UK. m.drysdale@vernalis.com |
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Abstract: | Heat shock protein (Hsp90) inhibitors are an increasingly interesting and important class of compounds where the first in class, natural product derived inhibitors such as 17-allylaminogeldanamycin (17-AAG), are entering late stage clinical development. Recently the emergence of synthetic, small molecule inhibitors has been described and both NVP-AUY922 and BIIB021 have entered clinical development. The medicinal chemistry of these and other published small molecule Hsp90 inhibitors is described in this review. |
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