| 大蒜素对脂多糖诱导的大鼠肺组织水通道蛋白-1表达的影响 |
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| 引用本文： | 陈华文,冯俊,易旻晓,祝伟,李树生.大蒜素对脂多糖诱导的大鼠肺组织水通道蛋白-1表达的影响[J].中国中医急症,2013(12):1999-2000,2021. |
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| 作者姓名： | 陈华文 冯俊 易旻晓 祝伟 李树生 |
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| 作者单位： | [1]华中科技大学同济医学院附属同济医院,湖北武汉430030 [2]华中科技大学同济医学院第二临床学院,湖北武汉430030 |
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| 基金项目： | 湖北省自然科学基金（2011CDB196） |
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| 摘 要： | 目的研究大蒜素对脂多糖（LPS）诱导的急性肺损伤（Au）大鼠肺组织中水通道蛋白（AQP）-I表达的变化，探讨AQP-1表达与ALI的关系。方法30只SD大鼠随机分为LPS组、大蒜素组和对照组，每组10只，在用药后6h检测肺组织AQP-1表达情况。结果与对照组比较，LPS组AQP-1蛋白和mRNA表达明显降低．大蒜素干预后AQP-1蛋白和mRNA表达明显上升。结论大蒜素可能通过抑制LPS诱导的大鼠肺组织AQP-1表达的降低达到改善ALI的作用。
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| 关 键 词： | 大蒜素 脂多糖 水通道蛋白 |
Effect of Allicin on Expression of AQP-1 in Pulmonary Tissues of Septic Rats |
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| Institution: | CHEN Hua-wen,FENG Jun1, YI Min-xiao2,et al. 1 Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Tech- nology,Hubei, Wuhan 430030, China;2 The Secong Clinical College, Toni Medical College ,Huazhong Universi- ty of Science and Technology,Hubei, Wuhan 430030, China |
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| Abstract: | Objective： To study the effect of allicin on expression of AQP-1 in the pulmonary tissues of mice with acute lung injury induced by lipopolysaceharide. Methods： 30 healthy SD mice were randomly divided into 3 groups： LPS group,allicin group and control group. ALI model was induced with LPS in all the LPS groups.Re- M-time PCR was used to observe the expression changes of AQP-1. Immunohistochemical method were used to determine the changes of AQP-1 protein in the pulmonary tissues of all the animals. Results： Compared with control group,the expression of AQP-1 were decreased in LPS group （P〈0.05）. After interfered with allicin,the expression of AQP-1 were increased （P〈 0.05）. Conclusion： Alliein can improve the pulmonary injury,and it may be related to allicin can inhibit the lower expression of AQP-1 in lipopolysaccharide-induced rats |
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| Keywords: | Allicin Lipopolysaccharide Aquaporins |
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