氟伏沙明联合阿立哌唑治疗强迫症对照研究

目的 探讨氟伏沙明联合阿立哌唑治疗强迫症的临床疗效和安全性.方法 将55例强迫症患者随机分为两组,均口服氟伏沙明治疗,观察组联合阿立哌唑治疗.观察6个月.于治疗前后采用Yale-Brown强迫量表评定临床疗效,副反应量表评定不良反应.结果 治疗后两组Yale-Brown强迫量表评分均较治疗前持续下降（P＜0.01）,观察组治疗各时段评分均显著低于对照组（P＜0.05或0.01）.治疗6个月观察组显效率、总有效率均高于对照组.两组不良反应均轻微,治疗各时段副反应量表评分及不良反应发生率比较差异均无显著性（P＞0.05）.结论 氟伏沙明联合阿立哌唑能增强抗强迫效应,治疗强迫症起效快,疗效显著,安全性高,依从性好,优于单用氟伏沙明治疗.

A control study of fluvoxamine combined with aripiprazole in the treatment of obsessive-compulsive disorder

Objective To explore the efficacy and safety of fluvoxamine combined with aripiprazole in the treatment of obsessive-compulsive disorder （OCD）. Methods Fifty-five OCD patients were randomly assigned to two groups, both groups took orally fluvoxamine, and observation group was plus aripiprazole for 6 months. Efficacies were assessed with the Yale-Brown Obsessive-Compulsive Scale （Y-BOCS） and adverse reactions with the Treatment Emergent Symptom Scale （TESS） before and after treatment. Results After treatment the Y-BOCS scores of both groups lowered continuously com- pared with pretreatment （P〈0.01）, those of all time points were significantly lower in observation than control group （P〈0. 05 or 0.01）. After 6 month treatment both obvious and total effective rate were higher in observation than control group. Adverse reactions of both groups were mild, there were no significant group differences in the TESS scores and the incidences of adverse reactions at all time points （P〉 0.05）. Conclusion Fluvoxamine combined with aripiprazole could strengthen anti-obsession effect, takes effect more rapidly, and has an evident effect, higher safety and better compliance compared with single fluvoxamine in the treatment of obsessive-compulsive disorder.