阿立哌唑与利培酮对首发精神分裂症患者血清催乳素水平的影响

目的 探讨阿立哌唑与利培酮对首发精神分裂症患者临床疗效和血清催乳素水平的影响.方法 将64例首发精神分裂症患者随机分为两组,每组32例,分别口服阿立哌唑与利培酮治疗,观察6周.于治疗前后采用阳性与阴性症状量表评定临床疗效,并检测血清催乳素水平的变化.结果 治疗后两组阳性与阴性症状量表总分均较治疗前有显著下降（P＜0.01）,治疗6周末两组显效率、有效率比较差异无显著性（P＞0.05）.阿立哌唑组治疗第2周末起血清催乳素水平较治疗前持续下降,而利培酮组则呈持续性升高（P＜0.01）.阿立哌唑组治疗各时段血清催乳素水平均显著低于利培酮组（P＜0.01）.结论 阿立哌唑与利培酮均能有效改善首发精神分裂症患者的各种精神症状,但阿立哌唑对患者的血清催乳素水平和体质量的影响较小,更有利于提高患者的治疗依从性.

The influence of aripiprazole and risperidone on serum prolactin levels of first-episode schizophrenics

Objective To explore the influence of aripiprazole and risperidone on serum prolactin levels of first-episode schizophrenics. Methods Sixty-four first-episode schizophrenics were randomly divided into two groups of 32 patients each and treated with aripiprazole or risperidone orally for 6 weeks. Before and after treatment efficacies were assessed with the positive and Negative Syndrome Scale （PANSS） and changes of serum prolactin levels detected. Results After treatment the PANSS scores of both groups lowered more significantly compared with pretreatment （P〈0.01）, there were no significant intergroup differences in obvious effective and effective rate at the end of the 6th week （P〉0.05）. Since the end of the 2nd week serum prolactin level lowered continuously in aripiprazole group and heightened in ripiprazole compared with pretreatment （P〈0.01）. Serum prolactin levels in all periods were significantly lower in aripiprazole than risperidone group （P〈0. 01）. Conclusion Both aripiprazole and risperidone could effectively improve various kinds of mental symptoms of first-episode schizophrenics, but the former has less effect on serum prolactin levels and is beneficial to the improvement of patients＇ treatment compliance.