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Development of a high performance zinc-62/copper-62 radionuclide generator for positron emission tomography |
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| Authors: | Jamal Zweit Robert Goodall Mark Cox John W. Babich Gerard A. Potter Harbans L. Sharma Robert J. Ott |
| Affiliation: | (1) Joint Department of Physics, The Royal Marsden Hospital, SM2 5PT Sutton, Surrey, UK;(2) Department of Medical Biophysics, University of Manchester, M13 9PT Manchester, UK;(3) MRC Cyclotron Unit, Clatterbridge Hospital, L63 4JY Merseyside, UK;(4) Drug Development Section, Institute of Cancer Research, SM2 5NG Sutton, Surrey, UK;(5) Present address: Department of Radiology, Massachusetts General Hospital, 02114 Boston, MA, USA |
| Abstract: | Clinical utilisation of positron emission tomography could be enhanced by the availability of shortlived radionuclides derived from generator systems. The zinc-62/copper-62 combination is one such system which could be used as a source for a number of copper-62 radiopharmaceuticals. We have developed and optimised a high activity (5.6 GBq, 150 mCi) zinc-62/copper-62 generator to provide 62CU in a form that is suitable for direct labelling of pyruvaldehyde-bis-(N4-methylthiosemicarbazone)-copper(II), Cu(PTSM). The distribution coefficients of Zn(II) and Cu(II) between anion-exchange resin and various hydrochloric acid/organic solvent mixtures were measured. Based on these measurements a generator eluent of 0.3 M HCl/40% ethanol provided 62CU in >90% yield in a 3-ml volume. A very low 62Zn breakthrough of less than 3×10–7% was achieved. Copper-PTSM was successfully labelled with the no-carrier-added 62Cu eluent directly from the generator with 94% radiochemical yield.Offprint requests to: J. Zweit, The Royal Marsden Hospital |
| Keywords: | Radionuclide generator Zinc-62 Copper-62 Pyruvaldehyde-bis(N4-methylthiosemicarbazone) PTSM Positron emission tomography |
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