| 光激发竹红菌甲素产生自由基的自旋捕捉研究 |
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| 引用本文： | 卢景雰,郑建华,程龙生. 光激发竹红菌甲素产生自由基的自旋捕捉研究[J]. 北京大学学报(医学版), 1993, 0(2) |
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| 作者姓名： | 卢景雰 郑建华 程龙生 |
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| 作者单位： | 北京医科大学天然药物及仿生药物国家重点实验室(卢景雰)，中国科学院生物物理研究所(郑建华)，中国科学院生物物理研究所(程龙生) |
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| 摘 要： | 本文用自旋捕捉电子顺磁共振,以DMPO为自旋捕捉剂,研究竹红菌甲素的光敏机理。实验测得超氧阴离子和羟基自由基的自旋加合物波谱。根据自由基清除剂超氧化物歧化酶,叠氮化钠和乙醇对上述波谱的抑制效应,证实竹红菌甲素有较强的产生超氧阴离子和羟基自由基的能力。在光敏过程中,氧自由基的产生依赖于基质和溶剂与其相互作用的反应速率的竞争状况。
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| 关 键 词： | 竹红菌甲素 光敏化作用 活性氧自由基 自旋捕捉 |
A STUDY ON SPIN TRAPPING OF FREE RADICAL PHOTOINDUCED BY HYPOCRELLIN A |
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| Lu Jingfen National Laboratory of Natural and Biomimetic Drugs. A STUDY ON SPIN TRAPPING OF FREE RADICAL PHOTOINDUCED BY HYPOCRELLIN A[J]. Journal of Peking University. Health sciences, 1993, 0(2) |
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| Authors: | Lu Jingfen National Laboratory of Natural and Biomimetic Drugs |
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| Affiliation: | Lu Jingfen National Laboratory of Natural and Biomimetic Drugs |
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| Abstract: | The mechanism of photosensitization of Hypocrellin A (HA) was inverstigated by means of spintrapping-EPR with 5, 5 dimethyl-1-ppyrroline-N-oxide (DMPO) as a spin trap.The spin adduct spectraof superoxide anion (O_2) and hydroxyl radical (OH) have been obtained.Some scavengers were usedto elucidate the mechanism of photosensitization induced by HA. The results showed that HA has astrong ability to produce O_2 and OH. These active oxygen radicals may play an important role inphotosensitization and their production depends on their ground substance and solvent and the compe-tition between their reaction rates. |
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| Keywords: | Hypocrollin A Photosensitization Spin Trapping adduct Active oxygen radical |
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