| 胃癌中cyclinD_2和p27~(kipl)的表达及其意义 |
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| 引用本文： | 金东岭,刘现军,柴锡庆,任俊英.胃癌中cyclinD_2和p27~(kipl)的表达及其意义[J].肿瘤防治研究,2004,31(2):76-78,F002. |
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| 作者姓名： | 金东岭 刘现军 柴锡庆 任俊英 |
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| 作者单位： | 河北工程学院医学部
056029河北邯郸(金东岭，刘现军，柴锡庆)，河北工程学院医学部 056029河北邯郸(任俊英) |
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| 摘 要： | 目的 探讨cyclinD2 、p2 7kipl的表达与胃癌发生发展的关系。方法 用免疫组化方法检测cy clinD2 和p2 7kipl在 12 0例胃癌、2 0例胃粘膜非典型增生、3 0例正常胃粘膜中的表达。结果 cyclinD2 在正常胃粘膜、非典型增生、胃癌中阳性表达率分别是 3 .3 %、10 %、和 3 4 .2 % ,胃癌与正常胃粘膜及非典型增生相比有显著性差异 (P <0 .0 1) ,p2 7kipl在正常胃粘膜、非典型增生、胃癌中表达分别是 10 0 %、90 %、和 52 .5%。胃癌与其他两组比较有显著性差异 (P <0 .0 1) ,p2 7kipl表达缺失和cyclinD2 胞浆阳性者与胃癌的分化程度、浸润深度、淋巴结转移有关 (P <0 .0 1)。cyclinD2 和p2 7kipl表达呈负相关。结论 cy clinD2 和 p2 7kipl与胃癌的发生有密切关系 ,p2 7kipl的表达缺失及cyclinD2 胞浆阳性者与胃癌的进展有关 ,p2 7kipl可作为估计预后的重要指标
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| 关 键 词： | 细胞周期素D2 p27kipl 胃肿瘤 免疫组织化学 |
| 收稿时间： | 2003-01-17; |
Significance of cyclinD_2 and p27~(kipl) Expressed in Gastric Carcinoma |
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| JIN Dong ling,LIU Xian jun,CHAI Xi qing,et al Medical.Significance of cyclinD_2 and p27~(kipl) Expressed in Gastric Carcinoma[J].Cancer Research on Prevention and Treatment,2004,31(2):76-78,F002. |
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| Authors: | JIN Dong ling LIU Xian jun CHAI Xi qing Medical |
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| Institution: | JIN Dong ling,LIU Xian jun,CHAI Xi qing,et al Medical Department of Hebei Technology College,Handan 056029,China |
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| Abstract: | Objective To investigate the relationship between the expression of cyclinD 2 and p27 kipl in carcinogenesis and development of gastric carcinoma. Methods cyclinD 2 and p27 kipl were detected by S P immunohistochemical method in 120 cases of gastric carcinoma, 20 cases of dysplastic gastric mucosa and 30 cases of normal gastric mucosa. Results The positive expression rate of cyclinD 2 in cases with gastric carcinoma?dysplasia and normal gastric mucosa were 3.3% , 10% and ... |
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| Keywords: | cyclinD 2 p27 kipl Gastric neoplasms Iimmunohistochemistry |
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