| PLA微球持续释放rrIGF-1对2型糖尿病大鼠种植体骨结合的影响 |
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| 引用本文： | 王峰,宋应亮.PLA微球持续释放rrIGF-1对2型糖尿病大鼠种植体骨结合的影响[J].中国口腔种植学杂志,2009,14(2):81-82. |
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| 作者姓名： | 王峰 宋应亮 |
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| 作者单位： | 第四军医大学口腔医院种植科,陕西西安,710032 |
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| 摘 要： | 目的:通过可降解生物聚合物PLA包裹rrIGF-1制备局部持续释放系统,促进2型糖尿痛大鼠种植体骨结合率.方法:将建模成功的20只2型糖尿病大鼠(血糖值>300me/ml的GK大鼠)分为2组PLA微球组(MS group)和对照组(con-trol group),采用W/O/W双层乳液法制备负载rrIGF-1的PLA微球,做SEM、CLSM分析及释放动力学曲线,证实其持续释放能力后作用于MSgroup,然后分别于种植体植入4周和8周后作组织形态学分析,比较两组之间的差异.结果:用此法制备的PLA微球包裹率较高,有持续释放rrIGF-1的作用.PLA微球组(MS group)较对照组(control group)在种植术后4w和8w的BIC(骨-种植体结合率)和TVB(骨小梁容量)均较高(P
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Sustained release of recombinant rat Insulin-Like Growth Factor-1 (rrIGF-1)from polylactide(PLA)microspheres improve osseointegration of dental implants in type 2 diabetic rats |
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| WANG Feng,SONG Ying-liang.Sustained release of recombinant rat Insulin-Like Growth Factor-1 (rrIGF-1)from polylactide(PLA)microspheres improve osseointegration of dental implants in type 2 diabetic rats[J].Chinese Journal of Oral Implantology,2009,14(2):81-82. |
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| Authors: | WANG Feng SONG Ying-liang |
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| Institution: | WANG Feng(Department of Implant,School of Stomatology,Fourth Military Medical University,Xi'an,Shaanxi 710032,PR China) SONG Ying-liang(Department of Implant,School of Stomatology,Fourth Military Medical University,Xi'an,Shaanxi 710032,PR China) |
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