干姜人参半夏汤对妊娠小鼠生殖毒性影响的实验研究

目的：观察干姜人参半夏汤对妊娠小鼠致畸敏感期的影响。方法：将80只孕鼠随机分为空白组，千姜人参半夏汤低剂量组、中剂量组、高剂量组，每组各20只。各组于孕后第6天开始灌胃至第17天，妊娠第18天处死孕鼠，并观察各组孕鼠体质量、胚胎发育及胎仔外观。结果：与空白对照组比较，干姜人参半夏汤各剂量组孕鼠体质量增长缓慢，且中剂量组、高剂量组有显著性差异（P〈0．01）；活胎率、死胎率、吸收胎率及胎仔体质量差异均无统计学意义（P〉0．05）；高剂量组可见部分胎仔发育畸形，但差异无统计学意义（P〉0．05）。结论：干姜人参半夏汤低剂量对妊娠小鼠生殖功能及胚胎发育无明显影响，中剂量、高剂量对其有一定的影响。

Experimental Study the Influence of Ganjiang Renshen Banxia Decoction on Reproductive Toxicity of Pregnancy Mice

Objective：To observe teratogenic effect on the sensitive issue of Ginger Ginseng Decoction to pregnant mice. Methods：80 rats were divided into control group, Ginger Ginseng Decoction low-dose group, middle dose group and high dose group, each with 20. Ad- ministered at the beginning of each group after the first six days of pregnancy to 17 days, were sacrificed on day 18 of gestation in preg- nant rats and observed the body weight of pregnant mice, embryonic development and fetal appearance. Results Compared with the con- trol group, Ginger Ginseng Decoction each dose group body mass of slow growth and high dose group had significant difference（ P 〈 0. 01 ） ;live birth rate, stillbirth rate, pregnancy rate and absorption fetal body mass difference was not statistically significant （P 〉 0.05 ） ; visible part of the high-dose group fetal malformations, but no statistical significance （ P 〉 0.05 ）. Conclusion ： Ginger Ginseng Decoction on pregnant mice low doses of reproductive function and no significant effect on embryonic development, in high doses to exert some in- fluence.