血清胱抑素C与血清肌酐对急性肾损伤患者的早期诊断及预后评价

目的探讨血清胱抑素C与血肌酐对发生急性肾损伤患者的早期诊断及预后评价。方法选取平顶山市中医院收治的66例急性肾损伤患者作为观察者，另外66例未发生急性肾损伤的患者作为对照组。比较观察组和对照组患者各时间点血清胱抑素C的水平、血清肌酐的水平以及患者血清胱抑素C、血清肌酐对评价急性肾损伤的灵敏度。结果入院后，观察组患者血清胱抑素C的水平逐渐升高，而对照组患者血清胱抑素C的水平没有显著性变化；入院4h、12h、24h后，观察组患者血清胱抑素C的水平均显著高于对照组（P〈0．05）；入院12h、24h后，观察组患者血清肌酐的水平均显著高于对照组（P〈0．05）。血清胱抑素C对评价急性肾损伤的灵敏度比血清肌酐好（P〈0．05）。结论清胱抑素C能够比血清肌酐敏感并及早发现急性肾损伤，它可能是急性肾损伤患者早期诊断及预后评价的理想内源性标志物。

Clinical study of serum cystatin C and serum creatinine in early diagnosis and prognosis predictive value of acute kidney injury

Objective To assess the clinic value of serum cystatin C and serum creatinine in the prediction of acute kid- ney injury. Methods A total of 66 acute kidney injury patients were chosen as the observing group and another 66 healthy subjects as control group. The level of serum cystatin C and serum creatinine were detected. Results The level of serum cystatin C in patients with acute kidney injury was progressively increased since admission （ P 〈 0. 05 ）, while the level of serum creatinine was progressively increased since 12h after admission （P 〈 0. 05 ） ;The level of serum cysta- tin C and serum creatinine in acute kidney injury group were significantly higher than that in non - acute kidney injury group（P 〈 0.05） ,the diagnostic rate obtained by serum cystatin C index weresignificantly higher than that by the serum creatinine index（P 〈 0. 05 ）. Conclusion Compared to the conventional biomarkers, the earlier emergence of serum cystatin C can contribute better to early clinical diagnosis of acute kidney injury.