Nicotinamide induces male-specific body weight loss in the postnatal period through molecular regulation of the hypothalamus and liver |
| |
Authors: | Sua In Duk Shin Lee Boyoung Choi Min-Ju Kim |
| |
Affiliation: | Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon, Gangwon-Do 200-702, Republic of Korea |
| |
Abstract: | Molecular mechanisms of body weight control have been discovered recently and much research focuses on the hypothalamic regulation of food intake and the hepatic regulation of glucose utility. We previously reported that postnatal nicotinamide treatment reduced brain dopamine and body weight. To further investigate the differential effects of nicotinamide-mediated body weight loss, nicotinamide (i.p. 100 mg/kg) was injected into postnatal and adult mice twice a week for 4 weeks. Interestingly, following nicotinamide treatment, male postnatal mice displayed reduced body weight and spontaneous motor activity. No significant changes were observed in adult and postnatal female mice or adult male mice following nicotinamide treatment. In male postnatal mice, hypothalamic agouti-related peptide (AGRP) and proopiomelanocortin (POMC) levels were increased in the arcuate nucleus following nicotinamide treatment. Neuropeptide Y (NPY) levels were unchanged in both male and female mice. Additionally, nicotinamide-injected male postnatal mice had increased glucose 6-phosphatase (G6Pase) and decreased phosphoenolpyruvate carboxykinase (PEPCK) expression in liver. These results indicate that hypothalamic POMC and hepatic PEPCK are important molecules that mediate nicotinamide-induced weight loss in postnatal male mice. |
| |
Keywords: | Nicotinamide Body weight change Hypothalamus Food intake Metabolism Gluconeogenesis |
本文献已被 ScienceDirect 等数据库收录! |
|