Tratamiento de la endometriosis con 5 mg o 25 mg diarios de mifepristona durante 6 meses. Ensayo clínico aleatorizado,doble ciego |
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Authors: | Josep Lluis Carbonell i Esteve Orlando Perera Boza Ana María Riverón Cobo Jesús González Giuseppe Tomasi |
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Institution: | 1. Centro de Cirugía Mayor Ambulatoria, Clínica Mediterránea Médica, Valencia, España;2. Hospital Gineco-Obstétrico Docente Eusebio Hernández, La Habana, Cuba;3. Facultad de Química, Universidad del País Vasco, San Sebastián, España |
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Abstract: | ObjectivesTo evaluate the safety and efficacy of 5 mg and 25 mg doses of mifepristone for the treatment of endometriosis.DesignRandomized double-blind study.SettingEusebio Hernández Hospital, Havana, Cuba.SubjectsTwenty-six women laparoscopically diagnosed with endometriosis were included.TreatmentGroup I received one tablet of 25 mg mifepristone daily and group II received one tablet of 5 mg mifepristone daily for 6 months. Laparoscopy and endometrial biopsy were performed before and after treatment.Variable to evaluate efficacyReduction in the intensity of dysmenorrhea measured by a visual analogue scale.ResultsIn both groups reductions in the intensity of dysmenorrhea and dyspareunia were highly significant compared with initial values (P <.001). All the women were amenorrheic after 45 days of treatment.ConclusionsAt doses of 5 mg or 25 mg, mifepristone could be an alternative for the treatment of endometriosis. |
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Keywords: | Antiprogestá genos Endometriosis Mifepristona |
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