脆性组氨酸三联体与肺癌的临床病理学研究

目的:探讨抑癌基因FHIT在肺癌组织中的表达缺失及其与临床病理因素的关系.方法:采用免疫组织化学S-P法检侧40例肺癌组织中FHIT蛋白表达情况,以癌旁组织作对照.结果:FHIT蛋白表达阴性率在肺癌为65.00%(26/40),FHIT蛋白在肿瘤组织中的表达明显低于癌旁正常组织(P<0.05).其中鳞癌为38.46%(5/13),腺癌为77.78%(21/27),其差异有显著性(P=0.01).FHIT与组织学类型、分化程度及性别有相关性(P<0.05).与年龄、肿瘤大小、临床分期、有无淋巴结转移无关(P>0.05).结论:FHIT在肺癌中失表达或表达下降可能与肺癌的发生有相关性.

Expression of FHIT of lung cancer and its relation with PTEN and Ki-67 proteins

Objective:To investigate the non-expression of FHIT of lung cancer and the relationship between the non-expression of FHIT and clinincal and pathologic parameters in Xuanwei. Methods: The FHIT protein was tested by immunohistochemical method in 40 cases of lung cancer and 40 sampeas of peri-cancer lung tissue. Results:The negative expression rate FHIT was 65.00%.The rate of expression of FHIT proteins in tumor tissues was significantly lower than that in non-tumor tissues(P<0.05).There was a significant difference between squamous cell carcinoma 38.46%(5/13)and adenocarcinoma 77.78%(21/27) (P=0.01).FHIT was significantly correlated with the histology,degree of differentiation of tumor and sex(P<0.05).No correlation was observed between FHIT expression in lung carcinoma and proliferation (P>0.05). Conclusion: There is correlation between the non-expression of Fhit protein and the occurrence and development of lung cancer.