肺肿瘤癌基因与抑癌基因表达的研究

目的探讨癌基因与抑癌基因的表达与肺癌发生、发展的关系。方法对61例肺肿瘤标本，用免疫组化方法同时检测癌基因Bcl-2、抑癌基因视网膜母细胞瘤(Rb)、p53、p16。结果Rb与p16表达、p53与Bcl-2表达呈负相关(P<0．05)，Rb与p53表达、p16与Bcl-2表达呈正相关(P<0．05)。结论肺癌的发生与发展是癌基因激活、抑癌基因失活及细胞凋亡调控基因异常等多基因损害的积累过程和协同作用使各细胞增殖调控途径失控，最终导致肺癌发生并使肺癌发展。

THE STUDY ON THE EXPRESSION OF ONCOGENE AND ANTIONCOGENE IN LUNG CANCER

Objective:To explore into the relationship between the expression of oncogene and antioncogene and the development of lung cancer. Methods:This present research was carried out to check oncogene Bcl 2, and antioncogene Rb,p16,p53 in 61specimen of lung cancer (LC). The immunohistochemical technique was used. Results:The expression of Rb was negatively related to that of p16, and the same, p53to Bcl 2(P<0.05),while the expression of Rb was positively related to that of p53,and the same,p16to Bcl 2(P<0.05). Conclusion:the development of LC was the result of the action of multiple factors.This action led to a series of changes of genetics, and accumulative and cooperative progress of the damage to multiple genes ensued, such as the activation of oncogene,inactivation of antioncogene,and the disorder of regulation gene of cellular apoptosis, which made the ronte of cell proliferation and regulation out of control, which resulted in the onset, and which accelerated the development of LC.