| 耐力训练对衰老小鼠心肌Akt/mTOR信号通路的影响 |
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| 引用本文： | 李欣,丁树哲,卢健. 耐力训练对衰老小鼠心肌Akt/mTOR信号通路的影响[J]. 中国运动医学杂志, 2010, 29(1) |
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| 作者姓名： | 李欣 丁树哲 卢健 |
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| 作者单位： | 1. 华东师范大学体育与健康学院,上海,200241;绵阳师范学院体育与健康教育学院,四川,绵阳,621000
2. 华东师范大学体育与健康学院,上海,200241 |
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| 摘 要： | 目的:探讨耐力训练对衰老小鼠心肌Akt/mTOR信号通路的影响。方法:雄性2月龄SAMP8小鼠随机分为年轻对照组(n=12)、耐力训练组(n=12)和老年对照组(n=12),年轻对照组在3月龄时处死,老年对照组常规饲养至6月龄时处死。耐力训练组从3月龄开始进行3个月的跑台耐力训练至6月龄时处死,每周3次,每次40min。测定各组小鼠心肌重量并计算心系数,取心肌组织进行HE染色观察;使用实时荧光定量PCR技术测定心肌Akt/mTOR信号通路中Akt、mTOR、p70S6K和eIF-4E mRNA的表达。结果:耐力训练组小鼠心脏重量和心系数与老年对照组相比显著增加(P<0.05),组织学检测未发现其心肌细胞出现病理性改变。老年对照组小鼠心肌Akt、mTOR、p70S6K和eIF-4E mRNA表达与年轻对照组相比显著下降(P<0.05);耐力训练组心肌各靶物质mRNA表达较老年对照组显著增加(P<0.05),低于年轻对照组,但不具有统计学意义。结论:耐力训练可以通过提高心脏Akt/mTOR通路中各信号分子的表达,使衰老心脏发生生理性的运动性心肌肥大。
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| 关 键 词： | 耐力训练 衰老 心肌 Akt/mTOR |
Effect of Endurance Training on the Cardiac Akt/mTOR Signaling Pathway in Aged Mice |
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| Li Xin,Ding Shuzhe,Lu Jian. Effect of Endurance Training on the Cardiac Akt/mTOR Signaling Pathway in Aged Mice[J]. Chinese Journal of Sports Medicine, 2010, 29(1) |
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| Authors: | Li Xin Ding Shuzhe Lu Jian |
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| Affiliation: | Li Xin 1,2,Ding Shuzhe 1,Lu Jian 11 School of Sports , Health Care,East China Normal University,Shanghai,China 2002412 Institute of Sports , Healthy Education,Mianyang Normal University,Sichuan,China 621000 |
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| Abstract: | Objective To study the effect of endurance training on the cardiac Akt/mTOR signaling pathway in aged mice.Methods Male 2-month-old SAMP8 mice were randomly divided into young control group(YC)(n=12),endurance training group(E)(n=12)and aged control group(AC)(n=12).The group YC was executed at three-month old;and the group AC was executed at six-month old.The group E underwent a 3-month endurance training program(three times per week,40min once a day).After completion of the training programt,he ratio of he... |
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| Keywords: | endurance exercise aging heart Akt/mTOR |
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