| 缺血预处理对肝脏缺血再灌注损伤保护作用的实验研究 |
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| 引用本文： | 朱彤 庞雪冰. 缺血预处理对肝脏缺血再灌注损伤保护作用的实验研究[J]. 肝胆外科杂志, 1999, 7(3): 222-224 |
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| 作者姓名： | 朱彤 庞雪冰 |
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| 作者单位： | [1]同济医院器官移植研究所 [2]同济医科大学计划生育研究所 |
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| 摘 要： | 在大鼠肝脏缺血再灌注模型基础上建立稳定的缺血预处理模型，观察其保护作用，结果发现预处理与缺血再灌注组相比比清肝酶（ＡＬＴ，ＡＳＴ），透明质酸水平及肝组织局部ＭＤＡ含量均低，而组织ＡＴＰ含量及能荷值均高，形态学损伤改变轻；同时发现预处理组织腺苷含量明显高于缺血再灌注组。实验表明缺血预处理能有效减轻肝脏的缺血再灌注损伤，腺苷分子参与了这一保护机制。
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| 关 键 词： | 肝缺血 预处理 再灌注损伤 |
PROTECTIVE EFFECT OF ISCHEMIC PRECONDITIONING ON THE HEPATIC ISCHEMIA-REPERFUSION INJURY IN RATS |
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| Zhu Tong,Ye Qifa,Chen shi et al. PROTECTIVE EFFECT OF ISCHEMIC PRECONDITIONING ON THE HEPATIC ISCHEMIA-REPERFUSION INJURY IN RATS[J]. Journal of Hepatobiliary Surgery, 1999, 7(3): 222-224 |
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| Authors: | Zhu Tong Ye Qifa Chen shi et al |
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| Affiliation: | Zhu Tong,Ye Qifa,Chen shi et al.Institute of Organ Transplantation,Tongji Medical University,Wuhan430030 |
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| Abstract: | Using ischemic preconditioning model and hepatic ischemia-reperfusion model in rats,this study investigated the protective effect of ischemic preconditioning.The results showed:(1)The serum ALT,AST and HA in IP groups were lower than those in I/R group(P<0.05);(2)MDA content in liver tissue was lower but ATP content and EC were higher in IP group than those in I/R group(P<0.05);(3)Histological findings showed less injury in IP groups;(4) Live tissue adenosine content was high in IP groups.It was suggested that IP could reduced the hepatic injury caused by the ischemia-reperfusion.Adenosine played an important role in this protection mechanism. |
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| Keywords: | Ischemic preconditioningReperfusion injuryLiver |
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