急性胰腺炎治疗过程中生长抑素对胃肠动力的影响

目的：观察急性胰腺炎（AP）治疗过程中生长抑素对胃肠动力的影响。方法从2012年8月至2013年7月共104例 AP 患者，随机将其分成两组。观察组患者给予生长抑素治疗，对照组患者则给予5-氟尿嘧啶治疗。同时，两组患者均实施胃肠减压和营养支持、禁食及对症支持、抗感染和解痉止痛等常规治疗。治疗5 d 后对比两组患者胃肠减压引流量，肠鸣音恢复正常的时间、肛门排便排气、腹胀和呕吐缓解情况，以及两组患者症状缓解情况和治疗效果。结果观察组显效35例，有效15例，总有效率为96.2%（50/52）；无效2例，占3.8%（2/52）。对照组显效34例，有效14例，总有效率为92.3%（50/52）；无效 4例，占7.7%（4/52）。两组患者胃肠减压引流量比较差异无统计学意义（P 〉0.05），但两组患者在肠鸣音恢复正常的时间、肛门排便排气、腹胀和呕吐缓解情况比较，观察组均明显优于对照组，且差异有统计学意义（P 〈0.05）。结论在对 AP 患者进行治疗时，生长抑素对胃肠动力具有一定的改善作用。

Effect of somatostatin on gastrointestinal motility in the treatment of acute pancreatitis

Objective To observe the effect of somatostatin on gastrointestinal motility in the treatment of acute pancreatitis. Methods From August 2012 to July 2013,the 104 patients with acute pancreatitis（AP）were randomly divided into two groups. Patients in the observation group were treated with injection of somatostatin,and patients in the control group were treated with in-jection of 5-fluorouracil. Meanwhile,patients in the two groups were all given conventional treatment such as gastrointestinal de-compression,nutrition support,fasting,symptomatic support,anti-infective and relief of spasm and pain. After 5 days of treat-ment,the drainage volume of gastrointestinal decompression,bowel sounds recovery time,anus exhaust defecation,relief of ab-dominal distension and vomiting,as well as the relief of symptoms and treatment effects of the two groups were compared. Results In observation group,35 cases were markedly effective,and 15 cases were effective,the total effective rate was 96. 2% . Two cases were invalid,accounting for 3. 8% . In control group,34 cases were markedly effective,and 14 cases were effective,the total effective rate was 92. 3% . Four cases were invalid,accounting for 7. 7% . There was no significant difference in the drainage volume of gastrointestinal decompression between the two groups（P 〉 0. 05）,but the observation group was supe-rior to the control group in the bowel sounds recovery time,anus exhaust defecation,relief of abdominal distension and vomiting, and the differences were significant（P 〈 0. 05）. Conclusion During the treatment of patients with AP,somatostatin has certain improving effect on gastrointestinal motility.