| 粉防己碱对大鼠急性全脑缺血再灌注损伤的影响 |
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| 引用本文： | 祝晓光,刘天培.粉防己碱对大鼠急性全脑缺血再灌注损伤的影响[J].中国病理生理杂志,1999,15(6):545-547. |
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| 作者姓名： | 祝晓光 刘天培 |
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| 作者单位： | 1. 安徽蚌埠医学院药理教研室,蚌埠,233003
2. 南京医科大学药理教研室 |
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| 摘 要： | 目的：研究粉防己碱对大鼠急性全脑缺血再灌注时脑血流量的影响。方法：采用改良的大鼠四血管（双侧颈总和锁骨下动脉）结扎法，复制大鼠急性全脑缺血（３０ｍｉｎ）再灌注（５ｍｉｎ，６０ｍｉｎ）损伤模型。结果：粉防己碱能明显增加脑血流量，减少钙积累，减轻脑水肿。结论：粉防己碱对大鼠急性全脑缺血再灌注时神经原有较好的保护作用。
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| 关 键 词： | 脑缺血 再灌注损伤 铬放射性同位素 钙通道阻滞剂 |
The effects of Tetrandrine on acute complete cerebral ischemia - reperfusion injury in rat |
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| ZHU Xiao-Guang,LIU Tian-Pei.The effects of Tetrandrine on acute complete cerebral ischemia - reperfusion injury in rat[J].Chinese Journal of Pathophysiology,1999,15(6):545-547. |
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| Authors: | ZHU Xiao-Guang LIU Tian-Pei |
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| Abstract: | AIM :The effects of Tetrandrine ( Tet ) on acute complete cerebral ischemia-reperfusion ( I/R) injury in rats were studied. METHODS: This I/R model was produced by bilateral carotid artery (CCA) coupled with subclavia artery ( SCA) occlusion. RESULTS: Tet could increase cerebral blood flow (CBF),reduce Ca accumulation and decrease cerebral edema. CONCLUSION : Tet has a good protective effects on ceregral nerous injury induced by I/R in rats . |
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| Keywords: | Cerebral ischemia Reperfusion injury Chromium radioisotopes Calcium channel blockers |
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