PET in T-Cell Lymphoma |
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Authors: | Pier Luigi Zinzani |
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Institution: | Istituto di Ematologia "L. e A. Seràgnoli", Bologna, Italy. pierluigi.zinzani@unibo.it |
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Abstract: | Most non-Hodgkin lymphomas (NHL) are of B-cell origin; only about 10% are T-cell or NK-cell lymphomas. The clinical features
of T/NK-cell lymphomas differ from those of B-cell lymphomas: advanced stage and extranodal disease are more common and the
prognosis is worse. Several studies have confirmed that 2-fluorine-18]fluoro-2-deoxy-D-glucose (18FDG) uptake varies among
different subtypes of lymphoma, a disparity that can be explained by the differences in histology, proliferation of tumor
cells, and the ratio of viable tumor and reactive cells in the environment. These observations are based on investigation
of B-cell lymphomas. Positron emission tomography (PET)/computed tomography (CT) was found to be useful both at staging and
at measuring the therapeutic outcome after two to three cycles of chemotherapy (interim PET/CT). Several meta-analyses have
confirmed the role of PET in evaluating the viability of the residual tumor mass after treatment. 18FDG-PET has been proved
to have an excellent negative predictive value. Conversely, only a few studies have investigated the role of FDG-PET in T/NK-cell
lymphomas. This paper summarizes the current information regarding the potential use of PET/CT in patients with T-cell lymphoma. |
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