Boron neutron capture therapy as new treatment for clear cell sarcoma: Trial on different animal model |
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| Affiliation: | 1. Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586, Japan;2. Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-8558, Japan;3. Section of Translational Research, Hyogo Cancer Center, Akashi 673-8558, Japan;4. Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan;5. Division of Radiation Life Science, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan;6. Department of Pathology, Hyogo Cancer Center, Akashi 673-8558, Japan;7. Division of Pediatrics, University of Miyazaki, Miyazaki 889-1692, Japan;8. Department of Pediatrics, Saiseikai Shigaken Hospital, Ritto 520-3046, Japan;9. Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan;10. Department of Clinical Laboratory, Chugoku Central Hospital, Fukuyama 720-0001, Japan;11. Department of Pathology, USC Keck School of Medicine, Los Angeles, CA 90033, USA;1. Kyoto University Research Reactor Institute, Osaka 590-0494, Japan;2. Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, Tokyo, Japan;3. Center of Medical Education, Sapporo Medical University, Hokkaido, Japan;4. Medical Physics Department, Auckland Hospital, Auckland, New Zealand;5. The Shimizu Institute of Technology, Shimizu Corporation, Tokyo, Japan;1. Chemical Resources Laboratory, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan;2. Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan;3. Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan;1. Graduate School of Engineering, Kyoto University, Kyoto, Japan;2. Centre for Medical Radiation Physics, University of Wollongong, Wollongong, Australia;3. Institute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka, Japan;1. Proton Medical Research Centre, University of Tsukuba, Tsukuba, Japan;2. Departments of Otolaryngology Head and Neck Surgery, Japan;3. Radiation Oncology, Kawasaki Medical School, Kurashiki, Japan;4. Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan |
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| Abstract: | Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In our previous study, the tumor disappeared under boron neutron capture therapy (BNCT) on subcutaneously-transplanted CCS-bearing animals. In the present study, the tumor disappeared under this therapy on model mice intramuscularly implanted with three different human CCS cells. BNCT led to the suppression of tumor-growth in each of the different model mice, suggesting its potentiality as an alternative to, or integrative option for, the treatment of CCS. |
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| Keywords: | Biodistribution Clear cell sarcoma (CCS) Boron neutron capture therapy (BNCT) Neutron irradiation |
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