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Annual advances of integrative pharmacology in 2020
Authors:Ke-Wu Zeng  Ming-Yao Gu
Institution:State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;Department of Cell Biology and Medical Genetics,School of Basic Medical Sciences,Shenzhen University Health Science Center,Shenzhen 518061,China
Abstract:Major studies on the pharmacology of traditional herbs as well as active compounds have been introduced in this review over the previous 12 months. This annual integrative pharmacology review includes the reports published in 2020 on bioactive herbal extracts and novel compounds in traditional medicine. Pharmacological reports on traditional herbs as well as their active compounds for anticancer, inflammation, and metabolic diseases occupy dominant positions. Traditional medicines are still widely reported as a crucial treatment to exhibit anticancer efficacy in numerous human cancer cells. Moreover, the focus on the discovery of bioactive compounds from traditional medicines against mental disorders and neurodegenerative diseases seems to increase. The reports on bone loss and organ fibrosis treatments have notably gradually increased. Furthermore, studies of traditional herbs on cardiovascular and cerebrovascular diseases show a declining trend. These pharmacological reports in 2020 collectively show several crucial therapeutic targets and promising candidate compounds from traditional medicines for human diseases.
Keywords:Traditional medicine  Natural product  Pharmacology  Cancer  Inflammation  Infectious diseases
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