Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles |
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| Affiliation: | 1. Structural Biology Laboratory, London Research Institute, Cancer Research UK, London, UK;2. Dept. of Health Sciences, University of Milano—Bicocca, Italy;1. Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland;2. Institute for Transuranium Elements, Joint Research Centre - European Commission, 76125 Karlsruhe, Germany;3. Faculty of Medicine, University of Information Technology and Management in Rzeszów, ul. Sucharskiego 2, 35-225 Rzeszów, Poland |
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| Abstract: | Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of 221Fr and 213Bi when encapsulating 225Ac. |
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| Keywords: | Recoil retention Polymersomes Alpha radionuclide therapy |
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