血管内皮生长因子-C及其受体与原发性结直肠癌淋巴转移的相关研究

目的研究血管内皮生长因子-C(VEGF-C)及其受体(KDR)与原发性结直肠癌淋巴转移的相关性。方法74例结直肠癌手术标本,其中发现淋巴转移36例,未发现淋巴转移38例,应用免疫组织化学染色的方法测定原发灶和转移淋巴结的VEGF-C及其KDR的表达。结果VEGF-C在有淋巴转移原发灶组与转移淋巴结组表达差异无统计学意义(P>0.05),但均高于未发现淋巴转移原发灶组,差异有统计学意义(P<0.01)。KDR在有淋巴转移原发灶组与转移淋巴结组的表达差异无统计学意义(P>0.05),但均高于未发现淋巴转移原发灶组(P<0.01)。结论VEGF-C的表达增高主要与癌细胞基因突变有关,而与其所处的微环境、癌灶的大小及癌细胞密度无关。VEGF-C及其KDR表达的强弱与结直肠癌淋巴转移呈正相关。

The relationship between lymph node metastasis and expression of VEGF-C and its receptor in colorectal carcinoma

Objective To explore the correlation between lymph node metastasis and expression of VEGF-C and its receptor(KDR)in colorectal carcinoma.Methods Retrospectively 74 specimen of colorectal carcinoma,36 of them were identified with lymph node metastasis and 38 of them without.The expression of VEGF-C and KDR was examined by immunohistochemistry in primary mass and metastatic lymph node.Results There was no statistical difference of VEGF-C expression between primary carcinoma and metastatic lymph nodes in metastasis cases(P>0.05),while there was statistical difference in non-metastasis cases(P<0.01).The similar results could be found in expression of KDR.Conclusion The increase of VEGF-C expression had closely relationship with genic mutation than micro-environment,the size of carcinoma and the density of carcinoma.The expression of VEGF-C and KDR were relatively with lymphatic metastasis in colorectal carcinoma.