应用ROC曲线对肿瘤标记物CEA、CA199和AFP在直结肠肿瘤诊断中应用价值的评价

目的]应用临床诊断性能（ROC）曲线，对恶性肿瘤相关抗原CEA、AFP及肿瘤标记物糖类抗原CA199在直结肠肿瘤诊断中的应用价值进行评价。方法]采用电化学发光免疫分析法测定直结肠恶性肿瘤患者和良性直结肠疾病患者血清CEA、CA199和AFP，通过ROC曲线评价CEA、CA199和AFP在直结肠肿瘤诊断中的应用价值。结果]通过ROC曲线评价，3项指标CEA、CA199和AFP的ROC曲线下面积（AUC％）分别为69．3％、54.3％和49.5％。结论]通过ROC曲线评价，CEA检测指标对直结肠恶性肿瘤患者的诊断具有一定的临床应用价值，而CA199和AFP检测指标对直结肠恶性肿瘤患者的诊断价值不大。

Assessment of diagnostic value of tumor markers CEA, CA199 and AFP for coiorectai neoplasm by ROC curve

Objective] To assess the diagnostic value of tumor markers CEA, CA199 and AFP for colorectal neoplasm by ROC curve. Methods] The serum levels of CEA, CA199 and AFP were determined by electrochemoluminescent immunoassay in the patients with malignant colorectal diseases and those with benign ones, Then their diagnostic value was assessed by ROC curve. Results] The AUC was 69.3% , 54.3% and 49. 5% for CEA, CA199 and AFP, respectively, Conclusion] CEA has some diagnostic value for malignant colorectal diseases whereas CA199 and AFP have no diagnostic value,