| 尼莫地平减轻蛛网膜下腔出血后脑损伤 |
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| 引用本文： | 孙保亮,张苏明,王新成,夏作理,杨明峰,袁慧.尼莫地平减轻蛛网膜下腔出血后脑损伤[J].中风与神经疾病杂志,2003,20(6):498-500. |
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| 作者姓名： | 孙保亮 张苏明 王新成 夏作理 杨明峰 袁慧 |
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| 作者单位： | 1. 泰山医学院附属医院神经内科,山东,泰安,271000
2. 华中科技大学同济医学院附属同济医院神经内科,湖北,武汉,430030 |
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| 基金项目： | 山东省中青年学术骨干基金，山东省中医药科研基金( 2 0 0 1 - 81 )资助项目 |
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| 摘 要： | 目的 探讨尼莫地平对蛛网膜下腔出血(SAH)后脑损伤的防治作用。方法 用血管内穿刺法制作大鼠SAH模型。对SAH组和尼莫地平处理组观察24h内局部脑血流量(rCBF)和脑组织水、电解质含量的动态变化。结果 SAH后rCBF迅速降低，1h达最低值，24h内持续于低水平状态。SAH后6h、24h脑组织含水率和Na^ 含量明显增加，K^ 含量减低；脑组织Ca^2 含量在SAH后1h开始显著增加。尼莫地平对上述的指标均有改善作用。结论 尼莫地平可减轻实验性SAH后脑损伤。
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| 关 键 词： | 尼莫地平 蛛网膜下腔出血 脑损伤 防治作用 |
| 文章编号： | 1003-2754(2003)06-0498-03 |
| 修稿时间： | 2003年6月9日 |
Effect of nimodipine on brain injury secondary to subarachnoid hemorrhage |
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| SUN Bao-liang,ZHANG Su-ming,WANG Xin-cheng,et al..Effect of nimodipine on brain injury secondary to subarachnoid hemorrhage[J].Journal of Apoplexy and Nervous Diseases,2003,20(6):498-500. |
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| Authors: | SUN Bao-liang ZHANG Su-ming WANG Xin-cheng |
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| Abstract: | Objective To investigate the protective effect of nimodipi ne on brain injury secondary to subarachnoid hemorrhage (SAH).Methods Rat SAH models were established by an endovascular perforating method,and d ynamic changes of regional cerebral blood flow (rCBF),brain water and electrolyt es contents were determined in both SAH group and nimodipine treated group.Results In SAH group,rCBF decreased immediately after SAH being produced,and retained at low le vels within 24h. Brain water and sodium contents increased while potassium cont ent decreased at 6h and 24h. Brain calcium content increased significantly from 1h to 24h after induction of SAH. Above alterations in nimodipine treated group were not so obvious as those in SAH group.Concl usion Nimodipine may attenuate brain injury secondary to experimental SAH. |
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| Keywords: | Subarachnoid hemorrhage Brain edema Nimodipine |
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