硼卡钠对急性辐射损伤小鼠的防护作用

目的 考察硼卡钠(sodium borocaptate,BSH)对急性辐射损伤小鼠的防护作用。方法 以BSH为受试物,用⁶⁰Co γ射线对小鼠进行一次性全身照射,照射剂量为6 Gy,剂量率为0.8 Gy/min。照射后第3天、第14天检测外周血细胞计数,并于照射后第14天检测小鼠脏器指数。结果 照后第3天,BSH高剂量组血小板计数显著增加(P <0.05);照后第14天,与模型组比较,BSH中剂量组血小板计数显著增加(P < 0.01),胸腺指数、脾脏指数均显著升高(P < 0.05)。结论 BSH能显著提高辐照后小鼠的血小板水平,对急性辐射损伤小鼠免疫系统有保护作用。

Radioprotective Effects of Sodium Borocaptate on Acute Radiation - Injured Mice.

Objective To investigate the radioprotective effects of sodium borocaptate on acute radiation - injured mice. Methods BSH was administrated in peritoneal injection with 0.2 ml / 20 g. Mice were exposed wholely to 60Co γ- ray with the dose of 6 Gy （0.8 Gy/min）. The count of peripheral blood cells was detected at 3rd ,14th day after irradiation. Organ in- dex was detected at 14th day after irradiation. Results Compared to model control group, PLT of BSH （80 mg/kg） group in- creased significantly （ P 〈 0.05 ） at 3 rd day after irradiation, PLT, spleen index and thymus index increased significantly （ P 〈 0.01, P 〈 0.05 ） at 14th day after irradiation. Conclusion The results showed that BSH had protective effects on PLT and im- mune system of acute radiation - injured mice.