| SDF-1/CXCR4轴在肺癌中的表达及意义 |
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| 引用本文： | 杨斌. SDF-1/CXCR4轴在肺癌中的表达及意义[J]. 医学综述, 2014, 20(17): 3131-3132 |
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| 作者姓名： | 杨斌 |
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| 作者单位： | 昆明医科大学第三附属医院内二科,昆明,650018 |
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| 基金项目： | 云南省卫生科技计划项目 |
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| 摘 要： | 肺癌的转移和复发是造成肺癌患者死亡的主要原因,肿瘤细胞的趋化迁移能力日益引起人们的关注,目前对于肿瘤趋化迁移能力的研究多趋向于肿瘤细胞趋化因子方面。CXCR4是目前研究最多的趋化因子,其导致肺癌转移的传导通路和调节机制还有待进一步阐明,合理设计以它们为靶点的药物,将为肺癌的治疗开创广阔的前景。
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| 关 键 词： | 肺癌 趋化因子CXC亚家族受体4 基质源因子1 表达 |
Expression and Significance of SDF-1/CXCR4 Axis in Lung Cancer |
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| YANG Bin. Expression and Significance of SDF-1/CXCR4 Axis in Lung Cancer[J]. Medical Recapitulate, 2014, 20(17): 3131-3132 |
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| Authors: | YANG Bin |
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| Affiliation: | . (Internal Medicine Department Two, the Third Affiliated Hospital of Kunming Medical University, Kunming 650018, China) |
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| Abstract: | Lung cancer metastasis and recurrence are the main reasons for the death of lung cancer patients, and chemotaxis migration ability of tumor cells have been arousing concern increasingly. At present, the research in chemotaxls migration ability of tumor cells tend to focus on tumor call chemotactic factor, among which CXCR4 is the mostly studied so far. However,the function of CXCR4 in the related pathway and the regulating mechanism of the lung cancer metastasis still need further research. The rational design of drugs with them as targets will widen the prospect of the treatment for lung cancer. |
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| Keywords: | Lung cancer CXC subfamily receptor-4 Stroma derived factor 1 Expression |
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