HLA-DRB1 alleles genotyping in patients with rheumatoid arthritis in Chinese.

Objective: To explore the role of HLA-DRB_1 genes in the development of rheumatoid arthritis (RA) and the correlations between HLA-DR alleles and clinical manifestations of patients with RA. Methods: 86 patients and 106 race matched controls in whom HLADR typing was performed by the method of DNA amplification with sequence-specific primers (PCR-SSP)