生长激素联合阿司匹林在体外受精-胚胎移植周期中的应用

目的:探讨生长激素(GH)联合阿司匹林在体外受精-胚胎移植(IVF-ET)中,对卵巢低反应患者促排卵周期的作用。方法:先前IVF促排卵周期中卵巢低反应患者40例,随机均分为联合用药组和对照组,在对照组应用促性腺激素释放激素激动剂(GnRH-a)和促性腺激素(Gn)促排卵的基础上,联合用药组还加用GH和小剂量的阿司匹林。比较两种不同治疗方法的作用效果。结果:联合用药组与对照组比较可明显提高卵泡数(P(0.01)、获卵数(P(0.01)、MⅡ期卵母细胞数(P(0.01)、受精率(P(0.05);而优质胚胎数没有明显差异(P(0.05),妊娠率提高不明显(P(0.05)。结论:IVF-ET的促排卵周期中,联合应用GH和阿司匹林可提高卵巢低反应患者的卵泡数、获卵数及受精率。

Effects of Co-administration of Growth Hormone(GH) and Aspirin to Women During in vitro Fertilization and Embryo Transfer(IVF-ET) Cycles

OBJECTIVE: To study the effects of the co-administration of growth hormone (GH) and aspirin to women with suboptimal response to GnRHa/FSH hyperstimulation protocol during in vitro fertilization and embryo transfer (IVF-ET) cycles. METHODS: Forty cases of poor ovarian response in previous IVF-ET cycles were randomly divided into 2 groups: the studied group of GH and aspirin (n = 20), and the control group without GH or aspirin (n = 20). RESULTS: The co-administration of GH and aspirin significantly increased the rates of retrieved oocytes (P < 0.01), promoted the maturation of oocytes (P < 0.01) and improve the fertilization rates (P < 0.05). However, there were no statistically differences between the two groups in the number of replaced embryos (P > 0.05) and the pregnancy rate (P > 0.05). CONCLUSION: The co-administration of GH and aspirin to poor ovarian responders is effective to increase the rates of retrieved oocytes, promote the maturation of oocytes and improve the fertilization rate in IVF-ET.