| 局灶脑缺血脑水肿时强啡肽的含量变化 |
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| 引用本文： | 张天锡,卞留贯,赵卫国. 局灶脑缺血脑水肿时强啡肽的含量变化[J]. 中国临床神经科学, 1995, 0(1) |
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| 作者姓名： | 张天锡 卞留贯 赵卫国 |
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| 作者单位： | 上海第二医科大学瑞金医院神经外科，上海第二医科大学瑞金医院神经外科，上海第二医科大学瑞金医院神经外科 200025，研究生 200025 上海医科大学中山医院神经外科，200025 |
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| 基金项目： | 卫生部“八·五”攻关脑缺血脑水肿课题基金 |
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| 摘 要： | 应用兔大脑中动脉阻断(MCAO)局灶脑缺血模型,将实验动物随机分成4组:对照组C、脑缺血后2h、4h、24h(I_2、I_4、I_(21))组。放射免疫法测定脑组织和血浆中强啡肽(Dynorphin,Dyn)含量的时相变化,同时测脑组织H_2O、Na~+含量。结果发现MCAO后脑组织和血浆Dyn含量显增,且随时相递增,并与脑组织H_2O、Na~+变化呈正相关,提示Dyn可能参与脑缺血、脑水肿的发生发展。
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| 关 键 词： | 强啡肽 脑缺血 脑水肿 兔 |
Changes of Dynorphin Contents in Focal Cerebral Ischemia and Edema |
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| Zhang Tian-Xi,Bian Liu-Cuan,Zhao Wei-Guo. Changes of Dynorphin Contents in Focal Cerebral Ischemia and Edema[J]. Chinese Journal of Clinical Neurosciences, 1995, 0(1) |
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| Authors: | Zhang Tian-Xi Bian Liu-Cuan Zhao Wei-Guo |
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| Affiliation: | Zhang Tian-Xi,Bian Liu-Cuan,Zhao Wei-GuoDepartment of Neurosurgery,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025 |
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| Abstract: | By using the rabbit model of middle cerebral artery occlusion, experimental animals were randomly divided into 4 groups: control group and 2h, 4h, 24h groups after cerebral ischemia. Contents of Dyn A1-13 in brain tissue and plasma were determined by RIA, contents of H2O and Na+ in brain tissue were also measured. It was found that they were significantly increased compared to control and they changed much more with the delay of the cerebral is-chemic time. There were positive correlations between Dyn A1-13 and H2O, Na+. These results suggested that the increased contents of Dyn A1-13 after cerebral ischemia might be associated with the development of cerebral ischemic edema. |
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| Keywords: | Dynorphin Cerebral ischemia Brain edema Rabbit |
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