Accumulation of subcutaneous fat,but not visceral fat,is a predictor of adiponectin levels in preterm infants at term-equivalent age |
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Authors: | Yuya Nakano Kazuo ItabashiMotoichiro Sakurai Madoka AizawaKazushige Dobashi Katsumi Mizuno |
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Institution: | Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan |
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Abstract: | BackgroundPreterm infants have altered fat tissue development, including a higher percentage of fat mass and increased volume of visceral fat. They also have altered adiponectin levels, including a lower ratio of high-molecular-weight adiponectin (HMW-Ad) to total adiponectin (T-Ad) at term-equivalent age, compared with term infants.AimsThe objective of this study was to investigate the association between adiponectin levels and fat tissue accumulation or distribution in preterm infants at term-equivalent age.Study designCross-sectional clinical study.SubjectsStudy subjects were 53 preterm infants born at ≤ 34 weeks gestation with a mean birth weight of 1592 g.Outcome measuresSerum levels of T-Ad and HMW-Ad were measured and a computed tomography (CT) scan was performed at the level of the umbilicus at term-equivalent age to analyze how fat tissue accumulation or distribution was correlated with adiponectin levels.ResultsT-Ad (r = 0.315, p = 0.022) and HMW-Ad levels (r = 0.338, p = 0.013) were positively associated with subcutaneous fat area evaluated by performing CT scan at term-equivalent age, but were not associated with visceral fat area in simple regression analyses. In addition, T-Ad (β = 0.487, p = 0.003) and HMW-Ad levels (β = 0.602, p < 0.001) were positively associated with subcutaneous fat tissue area, but they were not associated with visceral fat area also in multiple regression analyses.ConclusionSubcutaneous fat accumulation contributes to increased levels of T-Ad and HMW-Ad, while visceral fat accumulation does not influence adiponectin levels in preterm infants at term-equivalent age. |
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Keywords: | Adiponectin Preterm infants Subcutaneous fat Visceral fat Postnatal growth |
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