Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compounds increasing thyroid hormone clearance |
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Authors: | GA Montoya V Strauss E Fabian H Kamp W Mellert T Walk R Looser M Herold G Krennrich E Peter B van Ravenzwaay |
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Institution: | 1. BASF SE, Ludwigshafen, Germany;2. metanomics GmbH, Berlin, Germany |
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Abstract: | For identification of toxicological modes of action (MoAs) a database (MetaMap®Tox) was established containing plasma metabolome consisting of approximately 300 endogenous metabolites. Each five male and female Wistar rats per groups were treated with >500 reference compounds over a period of 28 days. More than 120 specific toxicity patterns of common metabolite changes associated with unique MoAs were established. |
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Keywords: | Metabolomics Biomarker Thyroid Mode of action Pattern Toxicity |
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