阴囊Paget病的诊治分析(附23例报告)

目的:探讨阴囊Paget病的诊断、治疗、复发因素及预后,提高诊治水平。方法:回顾性分析本院1996～2008年诊治的阴囊Paget病患者的临床资料。结果:23例患者中,局限于一侧阴囊者15例,累及双侧阴囊及阴茎者8例;病变同侧腹股沟淋巴结肿大者3例(2例术后病理证实为转移癌,1例为炎症),双侧腹股沟淋巴结肿大者2例(1例术后病理证实为转移癌,1例为慢性炎症改变)。全部病例均经活检明确诊断,并均行手术治疗。术后定期随访2～68个月,其中术后局部复发5例,因远处转移死亡2例。结论:活检是早期诊断阴囊Paget病重要方法,病变处阴囊的早期广泛切除是治疗阴囊Paget病的首选治疗手段。

Diagnosis and management of scrotal Paget's disease: Report of 23 cases

Objective:To explore the clinical manifestation,management,recurrence factors and prognosis of scrotal Paget's disease.Methods:We retrospectively analyzed the clinical and pathological data of 23 cases of scrotal Paget's disease diagnosed and treated in our hospital from 1996 to 2008.Results:The disease was confined to one side of the scrotum in 15,and involved the whole scrotum and penis in 8 of the cases.Three patients showed enlarged inguinal lymph nodes in the same side,and 2 in both sides.All the cases were confirmed by biopsy and treated by surgery.Post-operative follow-up was conducted for 2-68 months,which revealed 5 cases of local recurrence and 1 case of death for systemic metastasis.Conclusion:Biopsy is proved to be important for the early diagnosis of scrotal Paget's disease,and extended excision of local lesion is a preferred management.